Journal of Autoimmune Disorders

Acute Gout Attack in Cameroonians and Oxidative Stress: Cause and Effect?

Aim: Hyperuricemia and urates crystals deposition which lead to acute gout are responsible for inflammatory processes and possibly oxidative stress. However uric acid has been described to have both oxidant and antioxidant properties. The aim of this study was to determine if there is an oxidative stress in acute gout in Cameroonians.

Methods: We made a case control study on 60 Cameroonians subjects including 30 people with acute gout and 30 other free of gout with same age and sex. Oxidative status where evaluated with 4 markers: Malondialdehyde, Catalase, Glutathione Peroxidase and Superoxide Dismutase.

Results: Acute gout was associated with high levels of Malondialdehyde, but no difference was observed between the other stress markers in the groups.

Conclusion: Acute gout patients have oxidative damages to lipids which could play a role in the pathogenesis of diseases associated with gout and represent a potential target for prevention of these affections.

Author(s):

J R Nkeck*, M. Singwé Ngandeu, V. Ama Moor, M. S. Doualla and W. F. Mbacham

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