Human infection by Coxiella burnetii, a zoonosis, is associated with the development of autoantibodies, though the clinical significance of these is unclear. We describe two patients with high-titer Q fever antibodies associated with autoimmune hepatitis (AIH) as demonstrated on biopsy and supported by autoantibody results. For one, the chronology of serologic results uniquely demonstrates the development of autoantibodies after Q fever antibodies were detected, providing supportive evidence that Coxiella burnetii infection may have been a trigger for autoimmune hepatitis.
Kunatum Prasidthrathsint, Michael D. Voigt, Judy A Streit
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