Abstract
Gut microbiota dysbiosis and altered tryptophancatabolism contribute to autoimmunity in lupus-susceptible mice
The autoimmune disease systemic lupus erythematosus (SLE) is characterized by the production of pathogenic auto- antibodies. It has been postulated that gut microbial dysbiosis may be one of the mechanisms involved in SLE pathogenesis. Here, we demonstrate that the dysbiotic gut microbiota of triple congenic (TC) lupus-prone mice (B6.Sle1.Sle2.Sle3) stimulated the production of autoantibodies and activated immune cells when transferred into germfree congenic C57BL/6 (B6) mice. Fecal transfer to B6 mice induced autoimmune phenotypes only when the TC donor mice exhibited autoimmunity.
Author(s):
Laurence Morel
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Journal of Autoimmune Disorders received 155 citations as per google scholar report
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