Journal of Autoimmune Disorders

Interactions between Immune Activation and Regulatory T Cells in Mycobacterium tuberculosis Infected Lymph Node

At sites of infection, cellular immune responses play a
pivotal role in control of Mtb infection with CD4+ T
cells having the central role. Following infection, CD4+
T cells undergo activation to control infection by producing
Th1 and Th17 cytokines. Polyfunctional T cells, have
been associated with protection against Mtb disease. On
the other side, immune responses are modulated by T
regulatory cells (Tregs). The relationship between Tregs
and immune activation at sites of Mtb disease is still not
clear . We showed that the proportion of activated CD4+
and Tregs in Lymph node mononuclear cells (LNMC)
was increased compared to peripheral blood mononuclear
cells (PBMC). The correlation between Tregs and activated
CD4+ T cells was stronger in LNMC than PBMC

Author(s):

Fouad Seghrouchni

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