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Abstract

Mesenchymal stem cells work against chronic inflammation in rats

The variety of chronic diseases caused by chronic inflammation is an unresolved problem in developed countries. In this regard, in modern medicine, there are no adequate, pathogenetic mechanisms of treatment or improving the life quality for people with the so-called "diseases of civilization." This study aimed to investigate the anti-inflammatory and immune modulatory capacity of mesenchymal stem cells (MSCs) in a rat model of secondary chronic inflammation of λ-carrageenan. The study was carried out on 132 male Wistar rats weighing 180-200 g, divided into 12 groups. The inflammation model was a chronic aseptic inflammation caused by an intramuscular injection of 10 mg λ-carrageenan (Sigma-Aldrich GmbH) into the right thigh


Author(s):

Nataliia Petryk



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